Medicinal Chemistry - Lead Generation
- Hit identification from rational drug design and virtual and focused screening
- Computational chemistry driven structure-based and ligand-based drug-design to optimize biological activity
- Hit validation by experienced medicinal chemists with a track record of lead generation and candidate selection
- Hit validation of clients screening hits by resynthesis and by early ADMET developability profiling
- Assessment of chemical hit tractability for downstream multiparametric lead optimization
- A prioritised list of validated leads to enter lead optimization
Our Services: Lead Generation
Lead Generation: hit identification and hit validation
Generation of high quality leads is a critical stage in the drug discovery process – the better the lead the more likely a high quality candidate compound will be identified rapidly.
We provide hit identification taking advantage of our computational chemistry and extensive experience of rational drug design.
Hits from these strategies or from clients screening campaigns are subsequently validated exploiting our medicinal chemistry expertise and our ADMET developability and PK capabilities resulting in high quality leads for progression to full lead optimization.
For more information please contact: info@nikemresearch.com