Medicinal Chemistry - Lead Optimization

• Extensive use of state of the art computational chemistry suites for ADMET and developability prediction
• Intelligent balance between parallel array and iterative synthetic chemistry approaches
• In vitro multiparametric profiling to address in parallel potency, selectivity, metabolic clearance, P450 interactions, hERG binding, membrane permeability, solubility, protein binding, etc.
• In vivo rodent PK
• Effective integration and interpretation of all data by our expert medicinal chemists
• A rapid, efficient cost effective design-synthesis-screen cycle
• Re-synthesis of optimized leads for pre-clinical toxicology
• Support for protecting your intellectual property (IP)